You may also download the custom curve fit library Release.exe to fit various equations to your dissolution data. Download the self-extracting file Dissolution Calculator.exe and double-click on it to obtain this notebook. Although primarily designed for geothermal reservoir studies and high-level nuclear waste isolation, TOUGH3 can be applied to a wider range of problems Software Read More ». Below you will find a quick summary of the TOUGH Software Suite, with links to more detailed information on each: TOUGH3 is the basic simulator for nonisothermal multiphase flow in fractured porous media. FEATURES AND THEORETICAL BACKGROUND KinetDS is software for curve fitting, designed particularly to describe the cumulative dissolution curve by a simple equation or set of equations. Bases on the type of data used to establish the relationship, three main levels are defined by the FDA.Graphical user interface (GUI), a high level of software automation, and free availability for commercial and noncommercial use. It should be kept in mind that a relationship does not imply a causality link between the in vitro data, in our case, and the in vivo data. Various definitions of in vitro–in vivo correlation have been proposed by the International Pharmaceutical Federation (FIP), the USP working group, and regulatory authorities such as the FDA or EMEA.IVIVC is more an in vitro–in vivo relationship than a strict correlation. Many studies reported in the late ’70s and early ’80s established the basic concept of IVIVC. IVIVC allows dosage form optimization with the fewest possible trials in man, fixes dissolution acceptance criteria, and can be used as a surrogate for further bioequivalence studies it is also recommended by regulatory authorities. A good correlation is a tool for predicting in vivo results based on in vitro data. Correlations between in vitro and in vivo data (IVIVC) are often used during pharmaceutical development in order to reduce development time and optimize the formulation.
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